Recently, Tong Liping, Associate Researcher of the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, and Researcher Wang Huaiyu, together with Zhu Jianhao, a professor at the City University of Hong Kong, have successfully developed a smart biomaterial with photothermal response, which can be used to promote the regeneration and repair of bone defects. Related papers were published in the journal Biomaterials (DOI: 10.1016 / j.biomaterials.2018.12.008) with the title of Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant. The first completion unit of the thesis is Shenzhen Advanced Institute, the first author is Tong Liping, and the corresponding author is Wang Huaiyu.
Hyperthermia is a traditional therapy with less damage to normal tissues. It has been widely used to treat many chronic diseases since ancient times. However, the conventional thermotherapy method is limited by the problem of low external direct heat transfer efficiency, and the therapeutic effect is relatively limited. With the rapid development of nanotechnology in recent years, nanophotothermotherapy has become a research hotspot in the field of tumor therapy, with obvious advantages such as wide application range, strong selectivity and easy operation.
Inspired by the research on tumor photothermal therapy, the team based on the previous research cooperation with Yu Xuefeng's research group on black phosphorus-based biomaterials (Angew. Chem. Int. Ed. 55, 5003, 2016; Small 13, 1602896, 2017; Adv. Sci. 5, 1700848, 2018), compounding black phosphorus nanosheets with biodegradable medical polymer PLGA to prepare a new orthopedic implant material with photothermal response. This new type of composite biomaterial only needs to add 0.2% of black phosphorus nanosheets, which can have a high light-to-heat conversion effect under the coverage of muscle tissue, and even has a near-infrared illumination even after implanted in the bone defect of rats Very strong light and heat response. The research team further research found that local photothermal stimulation in the range of 40 ~ 42 ℃ can significantly promote the tissue regeneration of bone defect sites, and the addition of black phosphorus nanosheets can also regulate the degradation of polymer substrates, so it can be used as Ideal orthopedic implant material. In this work, the R & D team also deeply discussed the molecular biological mechanism of photothermal promoting bone formation, providing a new idea for the functional design of orthopedic implant materials.
The research was supported by the National Natural Science Foundation of China, the Youth Promotion Association of the Chinese Academy of Sciences, the Shenzhen Peacock Team, and the STS Regional Key Project of the Chinese Academy of Sciences.
Black-phosphorus-based composite biomaterial: Regulates the degradation of PLGA substrate and can stimulate micro-heat to stimulate osteogenesis through photothermal conversion in near infrared light stimulation.
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